Self-control is a key factor conferring resistance to weight gain. Low self-control is a component of impulsivity, the tendency to act rashly without consideration of adverse consequences. Converging evidence from personality psychology, cognitive neuroscience and functional neuroimaging demonstrates that low self-control and impulsivity are associated with obesity and weight gain. Self-control is also a potential target for a broad range of therapeutic interventions, both behavioral and pharmacological. The speakers will review the human psychology and cognitive neuroscience of appetite control, its association to obesity and the potential for therapy.