Obesity, like cancer decades ago, has been treated as a single disease process with universal prevention and treatment strategies, rather than a fundamentally heterogeneous process with numerous underlying mechanisms and etiologies, each requiring unique prevention and treatment modalities. Obesity and related coronary heart disease, stroke, and other sequelae lead to increased health burden and billions of dollars in health care costs in the U.S. Examining sources of heterogeneity in obesity will improve recognition of disease pathways and lead to actionable steps in community and clinical practice to tackle potentially distinct physiological mechanisms, disease courses, and individualized behavioral responses that underlie successful weight management.
Kari North, PhD
Duration, Severity and Distribution of Obesity and Subsequent CVD Risk
Penny Gordon-Larsen, PhD FTOS
Subtypes of Obesity and the Variable Response to Therapy
Lee M Kaplan, MD PhD
Distinct Pathways of Genetic Effects in Central and Overall Obesity
Cecilia Lindgren, MSc PhD