From the perspective that obesity prevalence is driven primarily by hyperphagia and that treating obesity requires the development of new pharmacotherapies with greater efficacy than those currently available, this key lecture will examine the distributed neural control of food intake inhibition with an emphasis on identifying two types of intake inhibitory mechanisms. The first are those whose processing of gastrointestinal satiation signals can be shown to be amplified by leptin, glucagon like peptide -1, and/or oxytocin receptor signaling. The second are those that reduce food seeking and the motivation to obtain energy dense, palatable foods.
Treating the Hyperphagia Driving Obesity—Neural Mechanisms of Feeding Inhibition
Harvey Grill, PhD