The prevalence of obesity has increased in adults significantly in the last decade. According to the Centers of Disease Control, a 5-10% weight loss has been shown to help combat problems associated with obesity. The objective of this single-arm, retrospective study was to evaluate the impact of a precision medicine weight loss program, which incorporates clinical visits, an integrated mobile application (app) platform, and tailored nutritional programming.


Patients at a multidisciplinary clinic (i.e., Enara Health) were initially evaluated by a physician, including a full metabolic assessment; in-person follow-up was provided by a dietitian and fitness trainer. Patients self-selected between intense and rapid or gradual weight loss programs. Anti-obesity medications were selectively prescribed based on a personalized plan and clinical judgment. To enhance patient engagement and continuity of care between visits, participants also utilized app features including tailored educational content delivery and nutritional and behavioral feedback.


Data for 233 patients enrolled in this precision medicine weight loss program were analyzed. Patients at 3, 6, and 12 months lost on average 11.99% (11.6 ± 6.6 kg), 13.87% (13.2 ± 6.5 kg), and 11.16% (10.4 ± 6.0 kg) of baseline weight, respectively. Weight loss from baseline to all three points in time was significant (all p<0.0001)


Our study demonstrated that all patients who participated in this hybrid digital and in-person weight loss program lost >11% of their baseline weight across multiple time points. Leveraging the real-time connectivity, tailored elements, and engagement of a mobile app may benefit weight loss programs.